Oxalates are naturally occurring substances found in plants and produced inside the human body. Unfortunately, oxalates are anti-nutrients which interfere with the absorption of minerals and can form sharp, knife-like crystals in the body which get lodged in tissues and organs, causing pain and inflammation. While the body can handle low to moderate amounts of oxalates, problems develop when there are excessively high levels of oxalates, which can occur due to a number of factors.